Dry syndrome is a chronic systemic immune disease that does not heal on its own. After the onset of the disease, the disease progresses slowly, but can involve multiple systems and organs with lesions, such as dry mouth, dry eyes, arthritis, liver and kidney lesions. Clinically, there is no cure for this disease, but the development of the disease can be delayed or the discomfort can be relieved by active treatment. If the secretory glands are involved, local treatment can be used; if the organs are damaged, systemic treatment, such as immunosuppressant combined with hormone therapy, is required. I. Local treatment: For those who have no internal organ damage, dry mouth, dry eyes and reduced exocrine glands, etc., clinical treatment is mostly directed at the symptoms.1. Dry mouth, dry eyes: Due to reduced exocrine glands, patients may have dry mouth, dry eyes and other symptoms, and can use artificial saliva, artificial tears, etc. to reduce the symptoms. You can also use drugs such as bromhexine and trichothecene as prescribed by the doctor to promote glandular secretion. In addition, patients should stop smoking and drinking alcohol in daily life and avoid taking drugs that cause dry mouth and eyes. If patients have severe dry eye symptoms, they can also be treated with closed tear dots, lid margin fusion, and lid bulb adhesion correction. 2. Joint pain: Patients with joint and muscle pain, accompanied by low-grade fever, can be treated with hydroxychloroquine, ibuprofen, and other medications under medical supervision. 2. Systemic treatment: For patients with severe disease and the presence of visceral damage, glucocorticoids and immunosuppressants, such as hydrocortisone, prednisone and cyclophosphamide, azathioprine, etc., may also be used as appropriate. If conventional treatment is not effective, or if there is arthritis, hematocrit, peripheral neuropathy, etc., biological agents such as rituximab can be used, which can improve the symptoms.