Ms. Lin received a kidney transplant from her husband and successfully overcame antigen rejection. Ms. Lin and Mr. Lin cut the cake together to celebrate. In the past, there were often sons who wanted to donate their livers to their sick fathers, or wives who wanted to donate their kidneys to their dialysis masters, but they regretted it because they were limited by the tissue pairing discrepancy; however, the hospital published yesterday a technology that can effectively remove the rejection antibodies from the recipient’s body, successfully breaking through the pairing barrier, so that families who wish to donate living organs such as kidneys, livers, and lungs to their loved ones in the future are no longer limited by the blood type or tissue pairing discrepancy, and can still be transplanted. The hospital recently performed a kidney transplant for a woman surnamed Lin, whose blood type is O and her husband’s blood type is B. The blood types are incompatible, and Ms. Lin has a hundred times more antibodies in her body than normal; in the past, physicians often advised patients to give up when they encountered this situation, but NTU overcame this immune system barrier; Ms. Lin said with emotion yesterday: Thank you to the transplant team for allowing my husband’s kidney to help me get a new life. The Department of Surgery physician Cai Mengkun pointed out that organ transplantation used to have three pairing hurdles, respectively, blood type, tissue antigen and cross-test, especially the latter, the pre-operative cross-test if positive, indicating that the transplant will occur hyper-acute rejection, the chance of failure is extremely high, usually the only way to give up the transplant. Ms. Lin went to the mainland seven years ago for a kidney transplant, and returned home because of severe rejection. Cai Meng Kun said, the hospital through the “rejection antibody fluorometric analysis technology”, quantitative analysis of antibodies that may lead to serious rejection found that Ms. Lin’s body antibody force price of more than 10,000; therefore, before transplantation, the need to remove rejection antibodies, including injection of drugs to remove B lymphocytes, plasma replacement surgery and injection of immunoglobulin, effectively inhibit the recipient’s antibody response, and in September last year to complete Mr. donated a kidney to his wife’s The wish to donate a kidney to his wife was fulfilled last September. Vice President of the hospital He Hongneng pointed out that women are more likely to produce organ rejection immune response, probably related to female hormones, pregnancy, blood transfusion and other factors. However, NTU surgery professor Li Bo Huang said that through the technology of removing rejection antibodies before transplantation, the immune barrier to organ transplantation can be successfully crossed, so in the future, five relatives within the intention to donate organs to sick relatives, do not have to be unable to help because of the matching problem. However, hospital director Chen Zhaolong said that the current live liver transplantation did not lymphocyte cross-test positive people, behavior transplantation contraindicated, mainly because the liver is more tolerant of organ transplantation, coupled with the liver has two sets of blood supply and regeneration capacity, so less subject to cross-test restrictions. Only he also believes that if the problem of tissue matching can be broken through, it will be of great help to expand the source of living organ donation. News Dictionary/Tissue Matching Cross-Testing In organ transplantation, if the tissue antigens of the organ recipient and donor match, they can coexist peacefully; if they do not, rejection can occur. Therefore, before transplantation, “tissue compatibility” must be considered and tissue antigen matching must be performed, including ABO compatibility, human leukocyte antigens (HLA), and whether the recipient has antibodies against the donor’s tissue antigens. If the test result is positive, transplantation is not advisable because hyperacute rejection will occur. However, the medical community has made significant breakthroughs in these matching hurdles.