There is no optimal clinical treatment for lumbar spondylolisthesis. Lumbar spondylolisthesis can be treated by general treatment, physical therapy and medication. 1. General treatment: patients with lumbar spondylolisthesis can walk, swim and other aerobic exercise to increase the stability of the joints. Patients with more obvious pain need to pay attention to rest, local warmth, and avoid overwork. 2. Physical therapy: lumbar spondylolisthesis patients can be relieved by hot compresses, massage, ultraviolet therapy and other physical therapy treatments. 3. Drug therapy: patients with lumbar spondylolisthesis can take non-steroidal anti-inflammatory drugs such as ibuprofen tablets, diclofenac sodium extended-release tablets, as well as vitamin B12 tablets, methylcobalamin tablets and other nutritive nerve medications to carry out treatment. The specific use of drugs should be used correctly under the guidance of a doctor, and it is recommended that patients consult a doctor in a timely manner, according to their own conditions for standardized treatment.