Xiang Sha Yang Gastric Pill is a proprietary Chinese medicine included in China’s National Basic Drug List, with a good safety profile and no adverse reactions clearly recorded in the drug instructions. However, clinical use requires evidence-based treatment in order to achieve better clinical results. In a study on the effect of Xiang Sha Yang Gastric Pill combined with Trimetbutine Maleate in elderly patients with functional dyspepsia, only one case of 57 patients showed dizziness and two cases showed drowsiness, and the adverse effects were mild. In a study in which Jiang Chunmei used Xiang Sha Yang Gastric Pill combined with Teprenone Capsules for the treatment of chronic atrophic gastritis, three cases of nausea, two cases of vomiting, and one case of vague pain were observed in 25 patients, with good overall safety. Reasonable use is also a prerequisite to ensure the safety of medication. In the process of taking Shantou Gastric Pills, we also need to pay attention to a light diet, avoiding tobacco, alcohol, spicy, cold and greasy; patients with stomach Yin deficiency mainly manifested as dry mouth and desire to drink, dry stools and short urine should not be used; allergic patients should be used with caution; people with chronic diseases such as hypertension, heart disease, liver disease and kidney disease should be taken under the guidance of a physician.