A nodular, dense shadow in the ascending colon usually suggests benign calcification of the intestinal wall or the presence of colon cancer, which can be diagnosed by colonoscopic biopsy. Benign calcifications do not require treatment, while colon cancer requires antitumor therapy such as radiotherapy and surgery. Benign calcification of intestinal wall is mainly caused by long-term inflammation stimulation, due to local inflammatory injury and proliferation repair, which is manifested as local calcification foci formation, no special treatment is needed, you need to pay attention to diet control, eat less spicy and stimulating food, eat more nutritious vegetables and fruits, moderate exercise, and maintain a good lifestyle. Ascending colon cancer can also lead to thickening and calcification of intestinal wall, as well as metastasis of surrounding lymph nodes. Therefore a colonoscopic tissue biopsy can be taken to determine whether the lesion is benign or malignant. If the results of the tissue biopsy are malignant, then anti-tumor therapy is required, such as surgery, radiotherapy and chemotherapy, and drugs are often used such as bevacizumab and regorafenib. The drugs need to be administered under medical supervision.