Although Gui Fu Li Zhong Wan has a wide range of uses, the claim that it has 21 new uses does not actually exist in clinical practice. Gui Fu Lizhong Pills are generally used to treat a range of conditions caused by spleen and kidney yang deficiency (deficiency of yang qi in the spleen and kidneys), with the effects of tonifying the kidneys and supporting yang, warming the middle and strengthening the spleen. Cold pain in the abdomen, constipation of the cold type, vomiting and diarrhea, edema, dysuria (unsmooth urination), and syncope of the extremities (cold extremities, even to the elbows and above the knees) caused by Yang deficiency of the Spleen and Kidneys can be regulated and treated with Gui Fu Lizhong Pills. The adverse effects of Gui Fu Lizhong Pill are not yet clear, and pregnant women should not take it. During the use of the medicine, one should closely observe one’s signs and consult a doctor or seek medical attention if there is any abnormality. Gui Fu Lizhong Pills should be taken under the guidance of a doctor and should not be used on its own to avoid adverse reactions.