Oral ulcers after autologous transplantation of myeloma patients may be due to the rejection reaction of bone marrow transplantation, or autologous transplantation and oral ulcers are not directly related, for oral ulcers, symptomatic treatment, pay attention to dietary habits can be. Due to the rejection of oral ulcers caused by myeloma autologous transplantation, patients should observe whether there are other symptoms, such as skin purpura, erythema, etc. If the above symptoms occur, they should consult a doctor in time to find out whether there is a rejection reaction. If there is rejection reaction, anti-rejection drugs such as glucocorticoid methylprednisolone should be used promptly. Oral ulcers and bone marrow transplantation may not be directly related, due to irregular diet, or diet is too stimulating, oral mucosal edema, thus inducing ulcers, for this situation, patients can take watermelon cream, reduce oral mucosal edema, generally can be healed. Myeloma autologous transplant oral ulcers are recommended to be treated under the guidance of a doctor, the above drugs are recommended to be used under the guidance of a physician.