Descending duodenal cysts do not usually go away on their own. Smaller cysts usually do not have significant discomfort, while larger cysts may have symptoms such as abdominal pain and bloating. Descending duodenal cysts are usually formed when long-term inflammation irritates the intestinal mucosa. They are generally benign lesions that cannot be absorbed on their own and will not disappear. Duodenal cyst belongs to benign cystic space-occupying lesions, and from the clinical data, the chance of cancerous transformation of this disease is relatively small. Smaller cysts will not compress the surrounding tissues and usually do not cause obvious discomfort. There is no need for special treatment. Pay attention to dietary improvement, eat less stimulating and spicy food, and have regular checkups to avoid the cysts from enlarging or developing lesions. Larger cysts will protrude into the intestinal lumen and may cause indigestion, abdominal pain and bloating, etc. Surgical resection will be performed if necessary. When a duodenal cyst develops, it is important to go to the hospital in a timely manner and be treated under a doctor’s supervision.