The effect of colchicine for leukosis can not be generalized, colchicine can treat leukosis, can play a role in reducing inflammation, relieve symptoms, the specific effect is related to each person’s condition and sensitivity to the drug. Leukemia, also known as Behçet’s disease, is a connective tissue disease with clinical manifestations of recurrent mouth ulcers and vulvar ulcers. The main principle of colchicine in treating leukosis is to inhibit neutrophil chemotaxis, reduce inflammation and relieve the symptoms of recurrent ulcers. The exact effect is related to each individual’s condition and sensitivity to the drug. Adverse reactions mainly include: gastrointestinal reactions such as diarrhea, abdominal pain, vomiting, loss of appetite, etc.; muscle and peripheral neuropathy such as muscle weakness, numbness, etc.; bone marrow transplantation can be thrombocytopenic; liver and renal function impairment. The drug is prohibited for those who are allergic to the components of the drug; prohibited for pregnant and lactating women; prohibited for those who have low bone marrow, as well as hepatic and renal insufficiency. It is important to check liver and kidney functions and blood tests regularly during the use of the drug, and female patients should not become pregnant during the period of taking the drug and for a few weeks after stopping it. Treatment of leukoaraiosis is recommended to choose the appropriate treatment program under the full assessment of the doctor to avoid the development of the disease.