Type B2 thymoma, i.e. cortical thymoma, has no uniform postoperative chemotherapy program, and the commonly used chemotherapeutic drugs include cisplatin, doxorubicin, cyclophosphamide, paclitaxel and so on. Cyclophosphamide combined with doxorubicin and cisplatin is often chosen as the first-line treatment for B2 thymoma, and there is no preferred option for second-line or back-line treatment. Commonly used chemotherapeutic drugs include etoposide, fluorouracil combined with calcium folinate, and paclitaxel, octreotide combined with prednisone can also be used for treatment. The choice of specific chemotherapy regimen for postoperative chemotherapy for B2 thymoma needs to be decided by the doctor. Due to individual differences, there is no such thing as the best or most effective medication, and doctors will adopt different treatment plans according to different conditions, so no generalization can be made. The chemotherapy regimen mentioned above is also for reference only, and the specific regimen should be based on the doctor’s decision. Thymoma is relatively sensitive to chemotherapy, so timely chemotherapy is recommended after B2 thymoma surgery to control the disease and prolong the survival rate. Patients are recommended to have regular treatment in time, and at the same time, regular follow-up is needed so that doctors can understand the changes of the disease and adjust the treatment plan appropriately.