The nerves through which the supraorbital fissure passes are the motoneuron, the buccal nerve, the abducens nerve, and the first branch of the trigeminal nerve. Common causes of damage are due to tumors, such as nasopharyngeal carcinoma and pituitary tumors, or vascular lesions, such as aneurysms and vasculitis, or infections, such as limited dural meningitis and supraorbital osteochondritis dissecans, or fractures, hemorrhages, and hematomas near the pterygoid winglets. These common etiologies can cause damage to the first branch of the trigeminal nerve, the motor nerve, the buccal nerve, and the abducens nerve, which may result in total ocular muscle paralysis as well as decreased facial sensation, dulled corneal reflexes, and manifestations of ipsilateral Horner’s syndrome.