The itching of rifampicin is considered an allergic reaction to the drug, which should be discontinued in time, and can be treated through general therapy and the use of anti-allergic drugs. 1. Discontinue medication: After taking rifampicin, itching symptoms should be discontinued immediately to prevent the symptoms from worsening. 2. General treatment: patients with itching symptoms after taking rifampicin should drink more water, eat a light diet, eat more vitamin-rich vegetables and fruits to help the drug metabolism and discharge. 3. Anti-allergic drug treatment: mild itching can be oral loratadine, ebastine and other antihistamines to reduce the allergic reaction, so as to achieve the role of relieving itching symptoms; itching can be used in severe prednisone, hydrocortisone and other glucocorticoid hormone therapy, such drugs have a strong anti-allergic effect. Rifampicin is contraindicated in patients with allergy, severe hepatic insufficiency, biliary obstruction, and early pregnancy. Taking rifampicin may cause adverse reactions such as nausea, vomiting, abdominal pain, itching, and elevated transaminases. Patients should take the drug as prescribed by the doctor, and should go to the hospital promptly for treatment when nausea, vomiting and other uncomfortable symptoms occur after using the drug.