Clopidogrel and aspirin can be taken interchangeably, but it is not recommended to take them interchangeably in clinical practice. Clopidogrel and aspirin can be used for antiplatelet therapy, the two drugs through different mechanisms to inhibit platelets, clinically used in the treatment of ischemic cardiovascular and cerebrovascular diseases. Clinically, clopidogrel and aspirin can be taken alternately, but this method is not recommended, each drug has a certain time to play the effect of the drug, the alternation of the drug may make the drug’s efficacy decline, resulting in inhibition of platelet aggregation of the efficacy of the reduction of the impact of the treatment of the disease. The adverse reactions of clopidogrel include stomach pain, diarrhea, constipation, skin and mucous membrane bleeding, gastrointestinal bleeding, cerebral hemorrhage, etc. It is forbidden to use it for patients who are allergic to the components of the drug, with active bleeding or active ulcers. Adverse reactions of aspirin include stomach pain, gastric distension, gastrointestinal bleeding, skin mucous membrane bleeding, respiratory distress, etc. It is contraindicated in patients with allergy to drug components, active ulcers, active bleeding, aspirin-related asthma, and blood diseases. When taking the above antiplatelet drugs, follow the doctor’s instructions for medication, avoid frequent changes in medication, so as not to affect the efficacy of the treatment.