Irbesartan is more likely to cause cough compared to temesartan. Patients taking Irbesartan in the process of occasional cough side effects, the probability of occurrence of clinical statistics between one percent to one in a thousand. Generally patients taking Irbesartan cough symptoms are mild, with a transient character, continue to take the drug can be tolerated, cough symptoms can be serious to consult a doctor to clarify the cause. Timosartan in the clinical drug trials did not observe the adverse effects of cough. Irbesartan and timosartan are both angiotensin II receptor antagonists, with the same pharmacological effects, and perform well in the treatment of essential hypertension and other diseases, which can reduce renal damage, reduce proteinuria, increase creatinine clearance, and protect renal function. Clinical often according to the patient’s condition and the doctor’s medication habits to choose the appropriate drug treatment, adverse reactions vary from person to person, if the patient is taking Irbesartan or Timosartan serious adverse reactions, it is recommended that the patient consult a doctor in a timely manner to clarify the cause of the disease, and then change the drug according to the condition.