Recently, Dr. Wu Xuejie, chief of urology department, successfully performed a retroperitoneal laparoscopic tumor resection for a patient with a huge adrenal tumor. The right adrenal tumor was nearly 7cm in diameter, and the right kidney was compressed and displaced, the tumor was adjacent to the liver, kidney, renal artery, inferior vena cava and abdominal aorta, and the surrounding relationship was complicated, plus the trophoblastic vessels around the tumor were crisscrossed and the surrounding space was narrow, so it became a veritable “small” forbidden area. The patient’s small stature (height 156cm) and short lumbar gap all bring great difficulties and challenges to the retroperitoneal surgery. According to the classification criteria of urology, adrenal tumors larger than 6 cm in diameter are defined as giant tumors. Since surgery for adrenal tumors often causes drastic changes in blood pressure and electrolyte fluctuations, open surgery has been used for such giant tumors in the past. After systematic study of the patient’s imaging data and detailed analysis of the difficulties and key points of the operation, we decided to perform trans-posterior laparoscopic minimally invasive surgery for him. During the operation, the patient made full use of his familiarity with the anatomical features of the adrenal region and the advantages of laparoscopic image magnification to perform anatomical freeing of the huge tumor of the right adrenal gland, and the tumor was completely and smoothly removed. The postoperative pathology report was adrenal ganglion cell tumor.