High creatinine 143μmol/L is beyond the normal range, elevated creatinine can be seen in physiological factors and pathological factors, generally physiological factors do not need treatment; pathological factors such as primary glomerulonephritis, diabetic nephropathy, etc., need to clarify the cause of the disease and then symptomatic treatment. 1. Physiological factors, such as high protein, eating a lot of meat, strenuous exercise, etc., can cause a transient increase in creatinine, which can be restored to normal level after vegetarian diet and rest. 2. Primary glomerulonephritis requires treatment to lower blood pressure and urinary protein, commonly used drugs include fosinopril and valsartan, etc. If necessary, glucocorticosteroids such as methylprednisolone and prednisone acetate can be applied, as well as immunosuppressants such as tacrolimus and cyclophosphamide. 3. Diabetic nephropathy requires strict control of blood glucose, and commonly used drugs include metformin, acarbose, dagliflozin, insulin and so on. Pathological factors indicate the existence of kidney damage. First of all, it is necessary to improve the relevant examination to clarify the specific cause of the disease, and then carry out the corresponding treatment; actively treat the primary disease, otherwise the renal function will continue to decline, and in severe cases, it may even lead to uremia. When the creatinine value is obviously abnormal, patients need to actively go to the hospital, complete the examination under the guidance of the doctor, and carry out targeted treatment after clarifying the cause of the disease, so as to avoid delaying the condition.