Repeated negative and positive nucleic acid tests for novel coronavirus may be related to infection or misdiagnosis and need to be continued with follow-up testing. The first consideration is related to infection with the novel coronavirus, which is a negative result if no infection occurs at the time of the first nucleic acid test. If the infection occurs later, the result will be positive, and after treatment, it will turn negative, but it may be possible to have a repeat positive result at a later stage. It is normal for the results of the nucleic acid test to change according to the infection status of the person being tested. It is normal for the nucleic acid test results to change as the person becomes infected. However, there may be false positives, where the person does not become infected, but a fragment of the NeoCoronavirus is found in the sample, which may be related to the NeoCoronavirus vaccine, environmental positives, etc., and then multiple retests are needed to avoid a false diagnosis.