High glutamyl transpeptidase may be caused by physiologic factors, acute viral hepatitis, intrahepatic or extrahepatic bile duct obstruction. 1. Physiological factors: Frequent overeating, heavy drinking, strenuous exercise, etc. may lead to high glutamyl transpeptidase. 2. Acute viral hepatitis: Liver cell damage in acute viral hepatitis can also cause high glutamyl transpeptidase. 3. Intrahepatic or extrahepatic bile duct obstruction: Intrahepatic or extrahepatic bile duct obstruction can affect the normal excretion of glutamyltransferase, which can lead to high glutamyltransferase. Diseases such as fatty liver, alcoholic hepatitis and alcoholic cirrhosis can also lead to high glutamyl transpeptidase, and it is recommended that patients should consult a doctor for diagnosis and treatment.