Taking TB medication may cause abdominal pain, but it does not always happen. The main anti-tuberculosis drugs are rifampicin, isoniazid, ethambutol, and pyrazinamide. Among them, the adverse effects of rifampicin, ethambutol, and pyrazinamide may be gastrointestinal in nature, and patients may experience abdominal pain, diarrhea, nausea and vomiting, and epigastric discomfort. The likelihood of abdominal pain is greatly increased with triple or quadruple dosing regimens, but not all patients experience it, depending on individual constitution. When patients take tuberculosis drugs appear to have abdominal pain, first of all to hospital for examination, diagnosis and symptomatic treatment. Patients should pay attention to a light diet during treatment with drugs, avoid eating stimulating food, try to light and easy to digest food, pay attention to dietary hygiene.