Inexplicable pain in the buttocks may be caused by several etiological factors, commonly pear-shaped muscle outlet syndrome, lumbar disc herniation, tumors, local infections and so on. 1. Piriformis outlet syndrome is sciatica, which occurs when the sciatic nerve is compressed by the piriformis muscle and the pain in the buttocks is aggravated, especially when the hip joint is abducted. 2. A herniated lumbar disc can compress the nerve roots that innervate the buttocks and cause buttock pain, which may be accompanied by low back pain, numbness of one side of the leg and numbness of the foot, and can be diagnosed by CT or MRI. 3. Tumors that can cause buttock pain may be sacrococcygeal tumors or tumors from other parts of the body metastasized to the sacrococcygeal area, which will invade and squeeze the surrounding tissues to produce buttock pain. 4. The soft tissues around the buttocks may cause aseptic inflammation because of sitting for too long, which may be accompanied by local skin redness, swelling, flushing and fever. If inexplicable pain in the buttocks, it is recommended to consult a doctor in time to identify the cause of the disease, the use of medication, please follow the doctor’s instructions.