Epilepsy and Tourette’s syndrome differ in etiology, clinical symptoms and treatment. 1. Etiology: Some epilepsy is secondary to other diseases, such as traumatic brain injury, brain tumor, intracranial infection, congenital developmental abnormalities, etc. Some epilepsy is related to heredity, and some of the causes are unknown. The etiology and pathogenesis of Tourette’s syndrome are unknown, partly caused by lesions of the basal nuclei, and some of them are related to psychiatric factors. 2. Clinical symptoms (1) Epilepsy: the clinical manifestations are characterized by seizures, transient, repetitive and stereotyped. It can be manifested as sensory, motor, consciousness, mental, behavioral, autonomic dysfunction or both. It can be seen at any age. (2) Tourette’s syndrome: It is characterized by rapid contraction of single or multiple muscles, fixed in one place or wandering, and is manifested by frowning, facial twitching, flaring of the nose and pouting. If the respiratory and articulatory muscles are involved, the twitching may be accompanied by involuntary articulation or obscene language. It is more common in children, and is obvious when they are nervous, but can be alleviated when they are relaxed. 3. Treatment: Epilepsy is mainly treated with medication, which can be combined with surgery if necessary. Commonly used drugs are sodium valproate, carbamazepine, lamotrigine, levetiracetam and so on. Tourette’s syndrome is mainly treated with medication and psychological counseling. The main drugs are haloperidol, sulpiride, thiopride or risperidone.