There are many reasons for the tickling cough during the daytime and nighttime, which are commonly associated with cough variant asthma, cardiac insufficiency, gastroesophageal reflux disease, and so on. 1. Cough variant asthma: a special type of asthma, mainly manifested as irritating dry cough, mostly at night and early morning episodes, without obvious wheezing, shortness of breath and other symptoms. It can be treated with inhaled glucocorticoids (e.g. budesonide) combined with bronchodilators (e.g. salbutamol). 2. Cardiac insufficiency: the night cough is mainly caused by the change of body position, which leads to blood stagnation in the lungs, causing pulmonary stasis and edema, thus causing night cough, which can be treated with sitting position, digoxin, furosemide, nitroglycerin and other drugs. 3. Gastroesophageal reflux disease (GERD): when lying down, acidic reflux may reflux into the throat, stimulating the throat and trachea, causing nighttime tickling and coughing, pharyngeal discomfort and other symptoms. The cough can be reduced by inhibiting gastric acid secretion through omeprazole, etc., and promoting gastric power through domperidone, etc. Daytime is fine a night tickling throat cough has many reasons, should promptly go to the hospital, clear cause, under the guidance of the doctor for treatment, to avoid delaying the condition. The drugs appearing above also need to be used under the guidance of a doctor.