Scratching the itchy skin without feeling is considered to be systemic scleroderma, peripheral neuritis, chronic lichen simplex and so on. 1. Systemic scleroderma: scleroderma is a connective tissue disease that mainly manifests itself as hardening of the skin and internal organs. It starts with Raynaud’s syndrome, which manifests itself as numbness of the skin when it is cold, so the skin has no feeling when it is being scratched. 2. Peripheral neuritis: peripheral neuritis is a variety of causes of motor, sensory and autonomic disorders of the distal limbs, mainly manifested as abnormal sensation of the distal part of the affected limbs, there may be ants, burning sensation and other symptoms, so when scratching the itch there may be no feeling in the skin. 3. Chronic lichen simplex: this is related to the dysfunction of cortical excitation and inhibition, scratching and chronic friction are the main triggers and aggravating factors, due to long-term scratching will lead to moss-like changes in the skin, and there will be a decrease in the skin sensation or no sensation when scratching. There may be other reasons for the lack of sensation when scratching the skin, so it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy.