Apolipoproteins are the protein portion of plasma lipoproteins, of which ApoA1 is one, and abnormalities are associated with certain diseases or diet, for example. The basic function of apolipoproteins is to transport lipids, and apo a1 is the most abundant of the group A apolipoproteins and is found mainly in HDL. High ApoA1 may be related to poor diet, long-term alcohol consumption, pregnancy and so on. Low ApoA1 may be associated with coronary heart disease, diabetes mellitus, chronic liver disease, nephrotic syndrome, acute myocardial infarction, familial α-lipoprotein deficiency, familial hypoHDL anemia, and so on. If ApoA1 is abnormal, it is recommended to consult a doctor in time to find out the cause of the abnormality and treat it in time under the doctor’s guidance.