A strong sense of weightlessness may be associated with heart disease such as coronary heart disease, but not absolutely, diseases such as Meniere’s disease can also cause similar symptoms, the treatment involved includes medication such as antiplatelet drugs, surgical treatment, and so on. 1. Coronary artery disease: Coronary artery disease causes the heart to be unable to provide sufficient blood, and also leads to symptoms such as cardiac hypertrophy, which can lead to a sense of weightlessness when the blood supply to the heart and cerebral vessels is insufficient. Treatment includes medication such as aspirin, clopidogrel, nitroglycerin, metoprolol, etc. If the condition is serious, it can be treated by percutaneous coronary intervention and coronary artery bypass grafting. 2. Ménière’s disease: Ménière’s disease is an otogenic vertigo disease caused by hydrops of the membranous labyrinth, with the main clinical symptoms of episodes of vertigo, severe weightlessness, tinnitus and ear distension. The main clinical symptoms are episodic vertigo, severe weightlessness, tinnitus and ear swelling, etc. The treatment includes medication such as Difenidol, aminopterin, etc., and labyrinthectomy for severe conditions. It is necessary to choose the appropriate treatment method under the guidance of the doctor. When patients experience discomfort, they should go to the hospital immediately.