Girls HPV58 positive, boys genitals and around without any abnormalities do not need special treatment, such as genitals appear abnormal feeling or naked eye visible abnormalities, should be timely to the regular hospital examination and treatment. HPV is the human papilloma virus, can cause human skin mucous membrane squamous epithelial hyperplasia. HPV58 belongs to the high-risk type, mainly through sexual intercourse or close contact transmission, or indirect contact with the virus contaminated goods and infection, infection can only stay in the local skin or mucous membranes, does not produce viremia, generally no obvious symptoms, not easy to be found, easy to form a persistent infection. HPV58 positive can be transmitted to sexual partners, after taking condoms and other isolation measures, can prevent infection. Girls should seek medical attention as soon as possible when they are HPV58 positive and accompanied by symptoms related to cervical lesions such as anal and genital warts and cervical carcinoma. Meanwhile, boys should be examined promptly and also treated if accompanied by symptoms such as warts.