Gastric wall thickening can be ruled out by alternating gastroscopy and barium meal examination, and if necessary, upper abdominal CT examination to observe the specifics of gastric wall thickness to rule out leather stomach. Leathery stomach is a type of gastric cancer, which mainly refers to the infiltration of tumor into submucosa, muscular layer and plasma layer, resulting in thickening of gastric wall, reduction of gastric lumen, hardening, and firmness like leather. Gastroscopy and barium meal are alternated, and if the whole stomach wall is found to be infiltrated by the tumor, then gastric cancer is considered. If tumor infiltration is not found in gastroscopy, but only congestion, swelling, erosion of gastric mucosa and thickening of gastric wall are found in CT examination of upper abdomen, gastric cancer can be excluded. It is recommended to go to the gastroenterology department of the hospital in time, improve the relevant examination and standardize the treatment under the guidance of doctors, pay attention to the light diet and strengthen the physical exercise to enhance the physical fitness in the daily life.