Large dandruff, may be due to androgenetic alopecia, seborrheic dermatitis, etc., can be improved by topical medication and daily protection. 1. Androgenetic alopecia: Hair loss due to excessive androgen, accompanied by increased oil secretion, dandruff, etc., can be improved by topical minoxidil, oral finasteride, regular daily routine and other ways to improve. 2. Seborrheic dermatitis: manifested as erythema, itching, flaking on the head, sometimes accompanied by oozing, can be used as a topical corticosteroid solution, at the same time, topical ketoconazole, selenium disulfide, etc., to improve the itching, flaking and other symptoms, and pay attention to the head of the daily cleanliness, can improve the clinical symptoms. In addition, the appearance of large flakes on the scalp, but also need to be alert to scalp psoriasis, need to seek professional physician differential diagnosis. The above medications should be used under the guidance of a physician. The appearance of large flakes on the scalp may also be due to other reasons, should go to the hospital for medical consultation, after clarification of the condition, to take targeted treatment.