In terms of the body’s response, the side effects of taking hypoglycemic drugs may be greater. Insulin itself is not metabolized by the liver and kidneys, while hypoglycemic drugs are metabolized by these organs, so patients taking oral hypoglycemic drugs need to have regular liver and kidney function tests. Due to the different specific conditions of patients, they should follow the doctor’s instructions to choose the most suitable way of lowering sugar. First, the side effects of insulin: 1, the occurrence of hypoglycemia: hypoglycemia is the most common side effects, with the type of insulin, the dose, and whether the patient injected insulin after eating, etc.; 2, increase body weight: insulin can promote the glucose in the blood into the liver cells, muscle cells, etc., the patient is prone to produce a sense of hunger, if the diet does not control the weight will be caused by the weight gain; 3, the emergence of drug resistance: type 2 diabetes mellitus patients If only insulin is used for treatment at the initial diagnosis, it may lead to an increase in insulin resistance, and it is usually necessary to take glucose-lowering drugs at the same time. When blood glucose control is better, insulin alone can be applied; 4, cause edema: patients applying insulin may have mild edema of the face and limbs. Second, the side effects of glucose-lowering drugs: 1, affecting digestion: the gastrointestinal tract has a certain degree of stimulation, such as acarbose tablets, may cause increased anal exhaust, abdominal pain, abdominal distension and diarrhea, etc.; 2, the emergence of drug resistance: some of the glucose-lowering drugs may have no effect in the beginning, or after a period of time after the use of medication is not effective; 3, the emergence of allergies: after taking glucose-lowering drugs, some patients will have skin allergic reactions, such as skin itching, rash, hives, etc.; 4, cause edema: such as pioglitazone hydrochloride, may cause water and sodium retention, which in turn leads to edema. The risk of hypoglycemia is higher in patients who take hypoglycemic drugs in combination or who inject insulin during drug administration. The main symptoms of hypoglycemia are hand tremors, panic, dizziness, etc. Patients with severe hypoglycemia may become unconscious. If hypoglycemia occurs, you should drink sugar water or take candy, etc. Patients who have been injecting insulin for a long time should change the injection site to avoid subcutaneous hardness. Patients who take glucose-lowering drugs for a long time should have their liver and kidney functions checked regularly. Patients with diabetes need to adhere to long-term medication, strengthen blood glucose monitoring, and at the same time, quit smoking and drinking, control diet, and exercise appropriately, but do not exercise on an empty stomach.