Prostate cancer with Gleason score of 4+5 and accompanied by bone metastasis can still be treated, and a variety of treatments such as drug endocrine therapy, chemotherapy and radiotherapy can be chosen according to the condition. Prostate cancer with pathology score of 4+5, indicating a high degree of malignancy and accompanied by bone metastasis, indicates that the tumor is already at an advanced stage, but there are still treatments available, and different treatment options need to be selected according to the condition. At present, androgen deprivation therapy is the most widely used basic treatment for metastatic prostate cancer, which is mainly to inhibit tumor progression by lowering the level of androgen, and the commonly used drugs are bicalutamide, goserelin and so on. Meanwhile, combination drug chemotherapy, such as docetaxel, can be chosen. If the pain of bone metastases is obvious, combined radiotherapy and other treatments can be chosen. All the above drugs need to pay attention to the side effects and adverse reactions of drugs, please use the above drugs under the guidance of a doctor. Please use the above drugs under the guidance of a doctor. Different conditions and different treatment plans, please go to a regular hospital and follow the advice of a specialist.