The stomach always feels empty and uncomfortable, may be a physiological phenomenon, may also be related to gastritis, peptic ulcer and endocrine diseases, gastric neurosis and other reasons. 1. Physiological phenomenon: after the stomach is emptied of food, the body is in a state of hunger, which will lead to the symptom that the stomach always feels empty. 2. Gastritis, peptic ulcer: chronic gastritis, gastric ulcer, duodenal ulcer and other diseases caused by various reasons may also appear in the stomach always feel empty phenomenon. 3. Endocrine diseases: diabetes, hyperthyroidism can lead to gastrointestinal tract peristalsis increased, causing the stomach always feel empty symptoms. 4. Gastric neurosis: mental and psychological factors can also lead to the symptoms of empty stomach. The above symptoms may also be related to other causes, it is recommended that patients go to the hospital in a timely manner, under the guidance of a professional physician to determine the cause of the disease, and comply with the doctor’s instructions for treatment.