Valsartan can be used in combination with calcium channel blockers, thiazide diuretics, beta-receptor antagonists and other drugs for the treatment of hypertension combined with chronic kidney disease, diabetes mellitus, angina pectoris and so on, but the specific effect of which is better needs to be analyzed comprehensively. Contraindications need to be noted when using drugs. 1. Hypertension combined with chronic kidney disease: the initial antihypertensive treatment can be only valsartan, in order to slow down the decline of renal function; when the blood pressure is not well controlled, it can be combined with amlodipine and other antihypertensive drugs. 2. Hypertension combined with diabetes mellitus: if you need a combination of drugs, you should use valsartan and other drugs as the basis, add hydrochlorothiazide and other diuretics, or nifedipine and other calcium channel blockers. However, it should be noted that diabetes combined with hyperuricemia patients should use diuretics with caution, and diuretics are prohibited in patients with gout. It is forbidden to combine with Aliskiren when using the drug. 3. Hypertension combined with angina pectoris: if you need to use a combination of drugs, valsartan can be added with beta receptor antagonists such as metoprolol. 4. Hypertension combined with chronic heart failure with reduced ejection fraction: on top of valsartan, diuretics such as hydrochlorothiazide and long-acting calcium channel blockers such as amlodipine and felodipine can be combined. Valsartan is contraindicated in cases of allergy to the components of valsartan, pregnancy and other conditions. The need for combination of drugs needs to be individualized by clinicians after comprehensive evaluation based on comorbidities and whether it is a special population. The above drugs need to be used under the guidance of clinicians, and unauthorized use is prohibited.