Creatinine 128 μmol/L can be seen in physiological increase such as strenuous exercise, eating too much meat, and pathological increase such as primary glomerular disease, etc. Usually, it can be recovered after removing triggers, while pathological increase is more serious and can be improved by general treatment and medication. Normally, physiological increase can be recovered after removing the trigger, and no special treatment is needed; pathological increase is more serious, and can be improved by general treatment and medication. Creatinine is the product of muscle metabolism in the body, mainly excreted by glomerular filtration. If creatinine 128μmol/L is physiologically increased, no special treatment is needed; if it is pathologically increased, general treatment and medication can be given. 1. General treatment: If creatinine is elevated due to primary glomerular disease, diabetic nephropathy, hypertensive nephropathy, etc., low-salt, low-fat and high-quality protein diet, such as chicken, etc., and try to avoid beans and legumes, seafood, animal offal, etc.; maintain balanced nutrition; and exercise appropriately in order to enhance immunity. 2. Drug therapy: elevated blood creatinine, can take detoxification and kidney protection drugs such as urethane granules, etc.; glucocorticoids such as methylprednisolone, etc.; immunosuppressant such as cyclophosphamide, etc.; at the same time, we also need to actively treat the primary disease, taking antihypertensive drugs such as enalapril, etc., hypoglycemic drugs such as insulin, etc., to control blood pressure and blood glucose. It is recommended to follow the doctor’s instructions to take the above drugs. If the creatinine is found to be elevated, it is recommended to consult a doctor in time and follow the doctor’s instructions to standardize the diagnosis and treatment, so as to avoid delaying the condition.