How is lymphomatoid papulosis treated? First, lymphomatoid papulosis, is a chronic, recurrent, self-healing, papular necrotic or papular nodular skin disease. The basic damage is papules and small nodules. It is clinically similar to acute pox-like furuncle, but histologically has features of cutaneous T-cell lymphoma, and ten to twenty percent of patients can develop another lymphoma sequentially or simultaneously. It is treated without specific therapy, and there is no evidence that treatment prevents the development of secondary lymphomas. However, if symptoms are present they can be treated appropriately, such as potent corticosteroids, PUVA systemic or localized, and topical application of carazapride can suppress damage without myelosuppression. Methotrexate MTX results in symptomatic improvement in ninety percent of patients, typical damage can be cured within eight weeks, and most tend to be chronic untreated and can develop new damage.