When both husband and wife are diagnosed with HIV infection at the same time, it is most likely that one of them is infected first, and when they do not check themselves and have unprotected sex, it is most likely that the other one will be infected. If both partners are infected with HIV, antiretroviral treatment should be started as soon as possible, and the couple should be treated together. Before antiretroviral treatment, it is necessary to complete a complete examination to clarify whether there are contraindications to certain antiretroviral drugs, and whether there are opportunistic infections, such as tuberculosis and Pneumocystis carinii pneumonia, etc. After the above conditions are ruled out, it is necessary to start antiretroviral treatment. After the above conditions are ruled out, the patient should be treated with drugs as soon as possible. Currently, the first-line antiviral treatment program is often used, including tenofovir, lamivudine, efavirenz, etc. The patient can also be treated with antiviral drugs according to the patient’s physical condition. The treatment program can also be adjusted according to the specific conditions of the patient’s body, but also alternative use of drugs, including abacavir, zidovudine, nevirapine, kleenex, and so on, in the process of treatment need to be closely followed up to observe the efficacy of the treatment.