Aripiprazole in combination with clozapine are both new antipsychotic medications that are often used in combination in clinical practice. Aripiprazole is primarily used to treat schizophrenia. It is important to note that aripiprazole has the potential to potentiate the effects of certain antihypertensive medications, such as quinidine, fluoxetine, and paroxetine. It should be used with caution when combined with other drugs that act on the central nervous system and alcohol. Clozapine tablets are effective not only for positive symptoms of psychosis, but also for negative symptoms. It is suitable for all subtypes of acute and chronic schizophrenia, and is effective for hallucinatory delusional type and adolescent type, and can reduce the emotional symptoms associated with schizophrenia. Aripiprazole used in combination with clozapine is used with caution in patients with anaphylactic rash, malignant syndromes, those with CNS depressive states, and patients with urinary retention. Liver function and electrocardiogram should be checked regularly, and blood glucose should be checked regularly to avoid diabetes or ketoacidosis. Aripiprazole taken in combination with Clozapine can further improve psychiatric symptoms, but more detailed information should be carefully consulted with your doctor and under his/her supervision.