Regurgitation of the mitral and tricuspid valves usually has both physiologic and pathologic causes. Physiologic causes are usually small amounts of regurgitation secondary to decreased arterial elasticity and increased brittleness in the elderly, and some patients will have small amounts of mild regurgitation, which is not a serious condition. However, in patients with severe regurgitation of the mitral and tricuspid valves, the disease is serious and must be treated aggressively, usually secondary to cardiovascular disease and pulmonary vascular disease. For example, rheumatic heart disease, infective endocarditis, rheumatoid arthritis, or long-term pulmonary hypertension can cause the diameter of the annulus to expand, leading to mitral and tricuspid valve closure insufficiency, the patient will have obvious regurgitation symptoms, such as chest tightness, shortness of breath, decreased activity tolerance, breathing difficulties, is a serious case, must be actively treated.