Medication mitral valve treatment focuses on controlling the symptoms of the disease and preventing the various complications that can arise from the disease. Mitral stenosis may have heart failure, atrial fibrillation, thrombosis and other complications. The treatment of medications includes prevention of rheumatic fever recurrence, prevention of infection and treatment of comorbidities. 1, heart failure: follow the general principles of heart failure treatment, diuretic, cardiotonic and vasodilator therapy. In acute pulmonary edema, avoid the use of vasodilators that mainly dilate small arteries. 2, atrial fibrillation: the treatment principle is to control the ventricular rate, strive to restore sinus rhythm, and prevent thromboembolism. (1) Acute attack with fast ventricular rate: if hemodynamically stable, the ventricular rate can be controlled below 100/min by intravenous injection of cetiran. If it is ineffective, amiodarone, cardioplegia, beta-blockers (medoxin, esmolol) or calcium antagonists (verapamil, diltiazem; in acute attack with pulmonary edema, shock, angina pectoris or syncope, immediate electrical cardioversion should be performed. (2) Chronic atrial fibrillation: If the duration of the disease is <1 year, the left atrial internal diameter is <60 mm, and there is no pathological sinus node syndrome or high atrioventricular block, drug (commonly used drugs are quinidine, amiodarone) or electrical resuscitation can be considered to restore sinus rhythm. An ultrasound should be performed to exclude intra-atrial appendage thrombus before resuscitation. After successful conversion, sinus rhythm is maintained with amiodarone or quinidine. For those who are not suitable for resuscitation, oral digoxin or combination of diltiazem, betalactam or aminoglutethimide should be used to control the ventricular rate to about 70 beats per minute at rest. 3. Indications for anticoagulation (1) Left atrial thrombus. (2) Previous history of embolism. (3) Prosthetic mechanical valve. (4) Atrial fibrillation. If there is no contraindication, better warfarin, control plasma prothrombin time prolongation 1.5-2 times; international standardized ratio 2.0-3.0. 3 weeks before and 4 weeks after resuscitation need to take warfarin anticoagulation therapy. When mitral stenosis is still in the left atrial compensatory phase, it is important to hurry up and do preventive work to avoid deterioration of the disease. 1, Prevention and control of rheumatic activity and treatment of streptococcal infection in the throat. 2, avoid strenuous activities and heavy physical labor. Some data show that when the heart rate increases from 70 times/min to 80 times/min during activity, the atrioventricular transvalvular pressure difference can be increased by 1 times. 3, pay attention to the combination of work and rest, diet should be light and rich in vitamins, so that the heart function in a longer period of time to maintain in the compensatory period, in order to slow down the progress of the disease. In most cases, drug treatment can only temporarily reduce the symptoms, can not cure the disease and control the progress of the disease, to lift the valve stenosis must be related to the surgical treatment can better control the development of the disease.