Ear pain after nucleic acid, may itself suffer from acute otitis externa, acute suppurative otitis media, middle ear cholesteatoma and other diseases, and nucleic acid collection has no direct correlation. 1. Acute otitis externa: digging the ear with too much strength, or after swimming into unclean water, can lead to acute otitis externa, resulting in ear pain. 2. Acute suppurative otitis media: the organism itself suffers from inflammation in the middle ear cavity, and the acute attack can be manifested as bouts of pain in the ear, or even pus outflow. 3. Middle ear cholesteatoma: middle ear cholesteatoma can cause destruction of bone around the ear, which can be followed by infection, and the pus is left in the middle ear cavity, which can cause different degrees of ear pain. It is recommended that the patient actively consult a doctor to check the disease and cooperate with the physician to standardize the treatment to avoid aggravation of the disease.