Skin ulceration pus should be local disinfection, anti-infection, surgery if necessary. 1. Local disinfection: iodophor, alcohol, saline, etc. can be used to fully clean the affected area and cover with sterile gauze or dressing. 2. Anti-infection: according to the severity of the disease, choose the appropriate anti-infection method. If the local infection is not serious, topical antibiotic ointment can be used, such as erythromycin ointment, mupirocin ointment, etc.; if accompanied by systemic symptoms or a more serious infection, oral or intravenous antibiotic treatment can be used, and according to the results of the patient’s bacterial culture, choose the sensitive antibiotics. 3. If the infection is serious, local tissue necrosis and pus are more, surgical treatment such as incision and drainage of abscess and debridement should be performed. In the above cases, you should go to the hospital in time and choose the appropriate treatment under the advice of the doctor to avoid aggravation of the infection and delay of the condition. All of the above drugs should be used under the guidance of a doctor.