Since Femstrom was first applied to clinical stone extraction in 1976, the minimally invasive nature of percutaneous renal puncture lithotripsy has been welcomed by urologists and patients, changing the situation that only open surgery was available for upper ureteral stones from renal calculi. However, percutaneous microchannel lithotripsy is a demanding operation with many complications, including the three key techniques of establishing working channels, lithotripsy and stone clearing. Especially for patients with polycystic kidney combined with stones, the puncture is more difficult, and many operators would rather choose the more complicated open surgery than risk PCNL surgery. The renal pelvis, after puncturing to the cyst site, cannot be found in time, and the fluid is still drawn out when sucking back, causing false impressions, blind needle entry, which will cause great damage, bleeding, and even lead to loss of the puncture site and failure of the whole operation, establishing the ideal working channel The ideal working channel should be the shortest distance from the kidney, reducing the damage to the kidney tissue, reaching all groups of renal calyces as much as possible, and dealing with the stones to the maximum extent. With the help of Sonix GPS real-time guidance, it helps to adjust the angle and direction of the puncture needle in time, which makes the positioning of the target renal calyces for puncture easy, accurate and fast. There was no case of serious intraoperative or postoperative complications, and the success rate of one puncture of the target calyces was improved with the help of Sonix GPS, which is safe and reliable and provides a new option for the localization of puncture in PCNL for the treatment of polycystic kidney combined with stones.