Hepatitis B minor two-positive refers to the two indicators of positive hepatitis B surface antigen and hepatitis B core antibody, usually seen in the process of transformation of hepatitis B major three positive to hepatitis B minor three positive, the disappearance of hepatitis B e antigen, but hepatitis B e antibody has not yet appeared. This situation often indicates that the disease is improving. In addition, during the transition from hepatitis B minor to hepatitis B major, the hepatitis B e antibody disappears at this time and a positive hepatitis B e antigen may appear next. The appearance of positive hepatitis B e antigen indicates that the body’s ability to replicate the hepatitis B virus has greatly increased, which also indicates that the disease is relapsing, which is a bad situation. This is a bad situation. Therefore, regular follow-up is needed for hepatitis B small second-positive, and a reasonable treatment plan should be formulated according to the specific condition.