Piriformis syndrome causes soreness in the calf muscles and can be treated with rest, physical therapy, and medication. Pear-shaped muscle syndrome patients pear-shaped muscle injury edema, congestion, spasm will compress the sciatic nerve appeared calf soreness and discomfort. Patients should have sufficient rest, and it is best to do bed rest. Through hot compresses, massage, acupuncture, tuina and other physiotherapy, to promote blood local circulation, promote the absorption of inflammatory substances to improve symptoms. Drugs can be oral anti-inflammatory analgesic drugs to relieve pain, such as diclofenac sodium, meloxicam and so on. Neurotrophic drugs such as methylcobalamin and adenosylcobalamin can also be taken orally. If symptoms of pyriformis syndrome appear, it is recommended that the patient go to the hospital for medical examination to clarify the cause of the disease and then treat the symptoms. The above drugs should be used under the guidance of a doctor, avoid self-medication.