Possible causes of dark spots on facial skin include nevus of Ota, chloasma, facial melanosis, etc., which can be improved with the help of medication and laser treatment. 1. Nevus of Ota: Nevus of Ota, also known as brownish-bronze nevus of the upper jaw of the eye, manifests itself as bluish-gray or grayish-brown spots or patches around the eye, temporal area, zygomatic area, forehead and other parts of the eye, with unclear boundary, which may be reticular or diffusely distributed. Such patients can use ruby laser, alexandrite laser, Nd:YAG laser and so on to help lighten the dark spots on the face, which have better therapeutic effect and rare side effects. 2. Chloasma: young and middle-aged women with dark spots on face may be caused by chloasma, which is mainly manifested as yellowish-brown or brown patches of different sizes and clear edges on zygomatic and cheek areas. Attention should be paid to strengthening sun protection; local application of hydroquinone cream, tretinoin, azelaic acid cream and other depigmenting agents can help to lighten the dark spots; if necessary, laser treatment, intense pulse light and other medical treatments can be used to help the treatment. 3. Facial melanosis: Facial melanosis is a kind of pigmentation disease occurring in the skin or mucous membrane, which is related to long-term constipation, taking anthraquinone laxative and exposure to photosensitizing substances, etc. The dark spots often start from zygomatico-temporal area and gradually spread to the cheeks, forehead and neck, etc. Patients with mild symptoms can apply topical hydroquinone cream to help lighten the dark spots. Patients with mild symptoms can apply local hydroquinone cream, compound arbutin cream, levitamin C serum and other drugs to help improve the dark spots; patients with severe symptoms can take oral multivitamins, aminocyclic acid tablets and other drugs to help promote the recovery of lesions. It should be noted that the above treatment and medication should be carried out under the guidance of a physician to avoid the occurrence of adverse reactions.