Herpes on the soles of the feet can cause herpes zoster, which can appear on the ipsilateral lower extremities and buttocks in addition to the soles of the feet, as clusters of small blisters, blood blisters, or pustules, accompanied by pain. Clinical treatment can be antiviral by taking oral valacyclovir hydrochloride pellets or famciclovir tablets and applying topical ganciclovir ointment or acyclovir ointment. If patients have severe pain they need to take oral pregabalin capsules to enhance pain relief treatment. It is also combined with adenosine cobalamin injection intramuscularly to nourish the nerves and promote nerve recovery. During the treatment period, it is necessary to avoid drinking alcohol, ensure good rest and sleep, and not to consume a lot of spicy and stimulating foods and hair products that cause aggravation of the disease.