Interferon generally includes common interferon as well as long-acting interferon, the former once every other day and the latter once a week. 1. Generic interferon: It is generally recommended to apply every other day. Generic interferon has certain therapeutic effects in treating chronic hepatitis B. 2. Long-acting interferon: It is generally recommended to be applied once a week, and the course of treatment usually takes 48 weeks, or can be extended by specialists according to the therapeutic effect. Long-acting interferon, compared with ordinary interferon, can achieve higher E antigen seroconversion rate, biochemical response rate and hepatitis B virus DNA. Adverse effects of interferon include fever, chills, headache, malaise, and muscle aches. Interferon is contraindicated in people who are allergic to interferon components, patients with severe heart disease, and patients with severe liver or kidney disease. In addition, it should not be used if there are abnormalities such as turbidity and precipitation. In addition, the application of interferon has certain risks, patients need to get the guidance of specialized doctors, and can not be applied without authorization.