High type III precollagen peptide is the result of blood sampling to check the four items of liver fibrosis, it is elevated not a certain disease, but suggests that the liver has a tendency to hepatitis, liver fibrosis, but also need to be combined with other indicators to make a comprehensive judgment. The four items of liver fibrosis include serum type III precollagen peptide (PC III), serum type IV collagen (V VI), laminin (LN), hyaluronidase (HA). The level of serum type III precollagen peptide is closely related to the degree of hepatic fibrosis, reflecting the status of hepatic fiber synthesis and inflammatory activity, in the early stage can be significantly elevated, but there is no specificity, the level of serum type III precollagen peptide can be elevated in the fibrosis of other organs, and the level of serum type III precollagen peptide may be elevated in the patients with old cirrhosis and part of the advanced liver cirrhosis and hepatic atrophy, but the serum type III precollagen peptide may not necessarily be elevated. Serum type IV collagen can reflect the collagen renewal rate of the basement membrane, which is an early marker of hepatic fibrosis and is suitable for the early diagnosis of hepatic fibrosis. Laminin is positively correlated with the degree of hepatic fibrosis activity and portal vein pressure, and is significantly higher in slow-living liver and liver cirrhosis and primary hepatocellular carcinoma. Hyaluronidase can more accurately and sensitively reflect the amount of fibers that have been generated in the liver and the damage to hepatocytes, and is mildly elevated in acute hepatitis, significantly elevated in chronic active hepatitis and extremely elevated in cirrhosis.