Glioma grade 3, generally referred to as glioma grade III, has been operated 2 times and recurred can be taken again for surgical treatment, drug treatment, radiotherapy, electric field treatment and so on. 1. Surgical treatment: If the patient’s health permits, he/she can undergo surgery again to remove the glioma after two surgeries and recurrence of glioma grade III. 2. Drug treatment: If there is an increase in intracranial pressure, hypertonic dehydration drugs such as mannitol and glycerol fructose can be used under the guidance of doctor. In addition, patients can also use temozolomide, nimustine, bevacizumab and other drugs as prescribed by doctors. 3. Radiotherapy: grade III glioma has been operated twice and recurrence can also be treated with radiation irradiation, which has a certain effect on lowering and slowing down the progression of the tumor. 4. Electric field therapy: electric field therapy is an anti-tumor treatment method to inhibit tumor cell division, which can be used to treat recurrent glioma. Glioma is difficult to be cured radically and often recurs after surgery. It is suggested that patients should seek medical treatment in time after recurrence, and doctors will treat them according to their conditions.