Patients with early stage of large cell neuroendocrine carcinoma should be treated mainly by surgery. For patients with late postoperative pathological stage or those who are already at advanced stage when discovered, they should be treated mainly by chemotherapy and radiotherapy, but there is still a lack of chemotherapy protocols for large cell neuroendocrine carcinoma in clinical practice. In general, patients with peripheral type can achieve radical treatment through surgical resection, but large cell neuroendocrine carcinoma, due to its own tumor characteristics, is prone to invade adjacent organs and organs, so it is often necessary to expand the scope of surgical resection. The patient’s general condition should be fully evaluated before surgery to choose a reasonable surgical approach, and more organ functions should be ensured as much as possible to avoid affecting the therapeutic effect due to too large a surgical resection range. For patients with intermediate and advanced stages who cannot tolerate surgery, radiation therapy and chemotherapy can be done. For some patients with poor health and low immunity can try Chinese medicine, immunotherapy and tumor vaccine, but there are no targeted drugs for large cell neuroendocrine cancer.