Thyroid nodule with hypothyroidism is generally not serious, if it is malignant nodule, there are symptoms such as dyspnea and compression of airways, and thyroid function is obviously hypothyroidism is more serious. 1. The nature of thyroid nodules: thyroid nodules can be categorized into benign and malignant, if they are benign, they are not serious and can be observed regularly; if they are malignant, they should be treated with surgery. 2. Clinical manifestations: if the thyroid enlargement compresses the trachea and esophagus, resulting in dyspnea and dysphagia, it is more serious and should be treated surgically. If hypothyroidism is severe, producing drowsiness, indifference or even coma, it is also serious. Thyroid nodules with hypothyroidism should be treated in a timely manner in a hospital under the guidance of a doctor.